/* ── Smart Trial Matcher ────────────────────────────────────────── */
:root {
  --navy:#0f172a; --navy-l:#1e293b; --p:#2563eb; --pd:#1d4ed8; --pl:#dbeafe;
  --a:#0ea5e9; --s:#10b981; --sl:#d1fae5; --w:#f59e0b; --d:#ef4444;
  --50:#f8fafc; --100:#f1f5f9; --200:#e2e8f0; --300:#cbd5e1; --400:#94a3b8;
  --500:#64748b; --600:#475569; --700:#334155; --800:#1e2937; --900:#0f172a;
  --r:10px; --rl:14px;
}

/* ── Nav ── */
.m-nav{position:sticky;top:0;z-index:100;background:rgba(255,255,255,.92);backdrop-filter:blur(12px);border-bottom:1px solid var(--200);padding:0 24px;height:56px;display:flex;align-items:center;justify-content:space-between}
.m-nav .logo{font-size:1.25rem;font-weight:800;color:var(--p);text-decoration:none}
.m-nav .nav-l{display:flex;gap:20px}
.m-nav .nav-l a{font-size:.875rem;color:var(--600);text-decoration:none;font-weight:500}
.m-nav .nav-l a:hover{color:var(--p)}

/* ── Hero ── */
.m-hero{background:linear-gradient(135deg,#0f172a 0%,#1e293b 60%,#2563eb 100%);color:#fff;padding:60px 24px 40px;text-align:center}
.m-hero h1{font-size:2rem;font-weight:800;margin-bottom:12px}
.m-hero p{font-size:1.05rem;opacity:.85;max-width:560px;margin:0 auto;line-height:1.6}

/* ── Container ── */
.m-container{max-width:720px;margin:0 auto;padding:0 24px}

/* ── Progress Bar ── */
.m-progress{display:flex;align-items:center;justify-content:center;gap:4px;padding:32px 0 16px}
.m-step-dot{width:36px;height:36px;border-radius:50%;display:flex;align-items:center;justify-content:center;font-size:.8rem;font-weight:700;border:2px solid var(--200);color:var(--400);background:#fff;transition:all .25s}
.m-step-dot.active{border-color:var(--p);background:var(--p);color:#fff;transform:scale(1.1)}
.m-step-dot.done{border-color:var(--s);background:var(--s);color:#fff}
.m-step-line{width:40px;height:2px;background:var(--200);transition:background .25s}
.m-step-line.done{background:var(--s)}

/* ── Step Panels ── */
.m-step-panel{display:none;animation:mFadeIn .3s ease}
.m-step-panel.active{display:block}
@keyframes mFadeIn{from{opacity:0;transform:translateY(12px)}to{opacity:1;transform:translateY(0)}}

.m-step-title{font-size:1.5rem;font-weight:800;color:var(--800);margin-bottom:8px}
.m-step-sub{font-size:.95rem;color:var(--500);margin-bottom:24px;line-height:1.5}

/* ── Condition Chips ── */
.m-chip-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(160px,1fr));gap:10px;margin-bottom:24px}
.m-chip{display:flex;align-items:center;gap:8px;padding:12px 16px;border:2px solid var(--200);border-radius:var(--r);cursor:pointer;font-size:.875rem;font-weight:600;color:var(--700);background:#fff;transition:all .15s}
.m-chip:hover{border-color:var(--p);background:var(--50)}
.m-chip.selected{border-color:var(--p);background:var(--pl);color:var(--pd)}
.m-chip .chip-icon{font-size:1.1rem}
.m-chip-other{padding:10px 14px;border:2px solid var(--200);border-radius:var(--r);font-size:.875rem;width:100%;outline:none;transition:border-color .15s}
.m-chip-other:focus{border-color:var(--p)}

/* ── Form Elements ── */
.m-form-group{margin-bottom:20px}
.m-label{display:block;font-size:.85rem;font-weight:600;color:var(--600);margin-bottom:6px}
.m-input{width:100%;padding:10px 14px;border:2px solid var(--200);border-radius:var(--r);font-size:.9rem;outline:none;transition:border-color .15s;font-family:inherit}
.m-input:focus{border-color:var(--p)}
.m-select{width:100%;padding:10px 14px;border:2px solid var(--200);border-radius:var(--r);font-size:.9rem;outline:none;background:#fff;font-family:inherit;cursor:pointer;appearance:none;background-image:url("data:image/svg+xml,%3Csvg xmlns='http://www.w3.org/2000/svg' width='12' height='12' viewBox='0 0 12 12'%3E%3Cpath fill='%2364748b' d='M6 8L1 3h10z'/%3E%3C/svg%3E");background-repeat:no-repeat;background-position:right 12px center}
.m-select:focus{border-color:var(--p)}

/* ── Radio / Checkbox Groups ── */
.m-radio-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(140px,1fr));gap:10px}
.m-radio-card{display:flex;align-items:center;gap:8px;padding:12px 16px;border:2px solid var(--200);border-radius:var(--r);cursor:pointer;font-size:.875rem;font-weight:500;color:var(--700);transition:all .15s}
.m-radio-card:hover{border-color:var(--p)}
.m-radio-card.selected{border-color:var(--p);background:var(--pl);color:var(--pd)}
.m-radio-card input{display:none}

/* ── Subtype Pills ── */
.m-subtype-row{display:flex;flex-wrap:wrap;gap:8px;margin-top:8px}
.m-subtype{padding:6px 14px;border:1px solid var(--200);border-radius:20px;font-size:.8rem;cursor:pointer;color:var(--600);background:#fff;transition:all .15s;font-weight:500}
.m-subtype:hover{border-color:var(--a);color:var(--a)}
.m-subtype.selected{border-color:var(--a);background:rgba(14,165,233,.08);color:#0284c7}

/* ── Biomarker Tags ── */
.m-bio-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(130px,1fr));gap:8px}
.m-bio{padding:10px 14px;border:2px solid var(--200);border-radius:var(--r);cursor:pointer;font-size:.82rem;font-weight:600;text-align:center;color:var(--700);transition:all .15s}
.m-bio:hover{border-color:var(--w)}
.m-bio.selected{border-color:var(--w);background:rgba(245,158,11,.08);color:#b45309}

/* ── Buttons ── */
.m-btn-row{display:flex;gap:12px;margin-top:28px;justify-content:space-between}
.m-btn{padding:12px 28px;border-radius:var(--r);font-size:.9rem;font-weight:700;border:none;cursor:pointer;transition:all .15s;font-family:inherit}
.m-btn-primary{background:var(--p);color:#fff}
.m-btn-primary:hover{background:var(--pd)}
.m-btn-secondary{background:var(--100);color:var(--600);border:1px solid var(--200)}
.m-btn-secondary:hover{background:var(--200)}
.m-btn:disabled{opacity:.4;cursor:not-allowed}
.m-btn-search{background:linear-gradient(135deg,var(--p),var(--a));color:#fff;padding:14px 40px;font-size:1rem;border-radius:var(--rl)}
.m-btn-search:hover{transform:translateY(-1px);box-shadow:0 4px 16px rgba(37,99,235,.3)}

/* ── Results ── */
.m-results{padding:24px 0 60px}
.m-results-header{margin-bottom:24px}
.m-results-header h2{font-size:1.4rem;font-weight:800;color:var(--800)}
.m-results-header p{color:var(--500);font-size:.9rem;margin-top:4px}
.m-relevance{display:inline-block;font-size:.75rem;font-weight:700;padding:3px 10px;border-radius:20px;margin-bottom:12px}
.m-rel-high{background:var(--sl);color:#047857}
.m-rel-med{background:#fef3c7;color:#92400e}
.m-rel-low{background:#fee2e2;color:#991b1b}

.m-trial-card{background:#fff;border:1px solid var(--200);border-radius:var(--rl);padding:20px;margin-bottom:16px;transition:box-shadow .15s}
.m-trial-card:hover{box-shadow:0 4px 12px rgba(0,0,0,.06)}
.m-trial-top{display:flex;justify-content:space-between;align-items:flex-start;gap:12px;margin-bottom:10px}
.m-trial-title{font-size:1rem;font-weight:700;color:var(--800);line-height:1.4;flex:1}
.m-trial-nct{font-size:.75rem;font-weight:600;color:var(--a);background:rgba(14,165,233,.08);padding:3px 8px;border-radius:6px;white-space:nowrap}
.m-trial-tags{display:flex;flex-wrap:wrap;gap:6px;margin-bottom:12px}
.m-tag{font-size:.75rem;padding:3px 10px;border-radius:20px;font-weight:600}
.m-tag-phase{background:var(--pl);color:var(--pd)}
.m-tag-status{background:var(--sl);color:#047857}
.m-tag-cond{background:var(--100);color:var(--600)}
.m-trial-details{display:grid;grid-template-columns:1fr 1fr;gap:10px;margin-bottom:12px}
.m-detail-item{font-size:.82rem}
.m-detail-label{color:var(--400);font-weight:600;margin-bottom:2px}
.m-detail-val{color:var(--700);font-weight:500}
.m-trial-why{background:var(--50);border-left:3px solid var(--p);padding:10px 14px;border-radius:0 8px 8px 0;margin-bottom:12px}
.m-trial-why-title{font-size:.8rem;font-weight:700;color:var(--p);margin-bottom:4px}
.m-trial-why-text{font-size:.82rem;color:var(--600);line-height:1.5}
.m-trial-actions{display:flex;justify-content:flex-end;gap:8px}
.m-trial-link{display:inline-flex;align-items:center;gap:6px;padding:8px 18px;border-radius:var(--r);font-size:.85rem;font-weight:600;background:var(--p);color:#fff;text-decoration:none;transition:background .15s}
.m-trial-link:hover{background:var(--pd)}

/* ── Loading ── */
.m-loading{text-align:center;padding:60px 24px}
.m-spinner{width:40px;height:40px;border:3px solid var(--200);border-top-color:var(--p);border-radius:50%;animation:spin .8s linear infinite;margin:0 auto 16px}
@keyframes spin{to{transform:rotate(360deg)}}

/* ── Summary Box ── */
.m-summary{background:var(--50);border:1px solid var(--200);border-radius:var(--rl);padding:20px;margin-bottom:24px}
.m-summary h3{font-size:1rem;font-weight:700;margin-bottom:12px;color:var(--800)}
.m-summary-row{display:flex;justify-content:space-between;padding:6px 0;font-size:.85rem;border-bottom:1px solid var(--200)}
.m-summary-row:last-child{border:none}
.m-summary-label{color:var(--500);font-weight:500}
.m-summary-val{color:var(--800);font-weight:600}

/* ── Responsive ── */
@media(max-width:640px){
  .m-hero h1{font-size:1.5rem}
  .m-chip-grid{grid-template-columns:1fr 1fr}
  .m-trial-details{grid-template-columns:1fr}
  .m-btn-row{flex-direction:column-reverse}
  .m-btn{width:100%;text-align:center}
}