Find recruiting clinical trials for Alzheimer's disease in the UK — including early onset, mild cognitive impairment (MCI), and APOE4+ subtypes. See treatment pathways and where trials fit in.
Free to use — Live data from ClinicalTrials.gov — Updated hourly
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Mild cognitive impairment or at-risk
Standard: Lifestyle interventions, anti-amyloid agents in trials
Mild symptoms, still independent
Standard: Cholinesterase inhibitors (Donepezil, Rivastigmine) + anti-amyloid therapy if eligible
Increasing dependence on others
Standard: Add Memantine (Namenda), adjust cholinesterase inhibitor
Significant care needs
Standard: Symptom management, behavioural strategies, or clinical trial
Alzheimer's diagnosed before age 65. Often has a stronger genetic component. About 5% of all Alzheimer's cases.
Noticeable cognitive decline that does not yet interfere significantly with daily activities. Some people with MCI progress to Alzheimer's.
Carriers of the APOE4 gene variant have a higher risk of developing Alzheimer's. Many prevention trials specifically target this group.
Loading trials from ClinicalTrials.gov...
Yes. Anti-amyloid therapies (Lecanemab, Donanemab) have shown significant promise in slowing disease progression. UK trials are also investigating anti-tau therapies, anti-inflammatory agents, and gene therapy approaches.
Absolutely. Many prevention and early intervention trials specifically target people with MCI. These trials aim to slow or prevent progression to Alzheimer's disease. Early participation is actively encouraged.
Most Alzheimer's trials include MRI or PET scans to monitor brain changes. Some may use amyloid PET scans or tau PET scans. These are provided at no cost to participants.
If the person lacks capacity to consent, a legally appointed representative (usually a family member with lasting power of attorney) can provide consent. The trial team will guide you through this process.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.