Find recruiting clinical trials for atrial fibrillation in the UK — including catheter ablation techniques, novel anticoagulants, left atrial appendage closure devices, and rhythm control strategies. See your treatment pathway and where trials fit in.
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Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Episodes that start and stop on their own within 7 days
Standard: Rate or rhythm control, catheter ablation, anticoagulation
Episodes lasting more than 7 days or needing treatment to stop
Standard: Cardioversion, antiarrhythmic drugs, catheter ablation
Continuous AF where rhythm control has been abandoned
Standard: Rate control, anticoagulation, left atrial appendage closure
Focus on anticoagulation and stroke risk reduction
Standard: DOACs (apixaban, rivarelbans), warfarin, LAAO devices
Trials testing new ablation technologies including pulsed field ablation (PFA), cryoablation, and RF ablation to isolate the pulmonary veins and restore normal rhythm.
Novel anticoagulants (DOACs) and factor XIa inhibitors aim to prevent strokes with lower bleeding risk than traditional warfarin.
Device-based alternatives to anticoagulation for patients who cannot tolerate blood thinners. The Watchman and Amulet devices are being studied in UK centres.
Wearable devices and AI algorithms for early AF detection and personalised treatment optimisation. Several UK trials are integrating Apple Watch and Zio patch data.
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Yes. Many trials specifically recruit patients already taking anticoagulants — testing whether new drugs or devices offer better stroke prevention with fewer side effects.
PFA is a new ablation technique that uses electrical pulses instead of heat or cold to treat AF tissue. It is more selective, causing less collateral damage to surrounding tissues like the oesophagus.
Yes. Many NHS hospitals participate in AF trials, especially for ablation techniques and anticoagulation. Your cardiologist can refer you to trials at your local heart centre.
A minimally invasive procedure that seals off the left atrial appendage — the part of the heart where blood clots most commonly form in AF patients. It is an alternative to long-term blood thinners.
Use our search above to find trials matching your condition and location. Review eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.