Find recruiting clinical trials for ME/CFS in the UK — including immune-modulating therapies, metabolic interventions, neurorehabilitation approaches, and digital health solutions. See emerging treatment areas and where trials fit in your care.
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Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Able to carry out most daily activities with modifications
Standard: Activity pacing, sleep hygiene, graded self-management, symptom monitoring
Significant reduction in activity, may need rest during day
Standard: Occupational therapy, pain management, cognitive support, energy conservation strategies
Unable to leave home or bed, minimal activity tolerance
Standard: Home-based specialist care, nutritional support, symptom management, carer support
Fatigue syndrome following viral infection
Standard: Rehabilitation programmes, cardiopulmonary assessment, neurologist referral, gradual reintroduction of activity
Trials testing low-dose naltrexone, rituximab, and other immune-modulating drugs that target the immune dysfunction thought to underlie ME/CFS. Some trials focus on specific immune markers to identify treatable subgroups.
Research targeting cellular energy metabolism, including trials of mitochondrial supplements, oxidative stress reducers, and drugs that address the energy production deficits seen in ME/CFS patients.
Innovative trials using transcranial magnetic stimulation (TMS), vagus nerve stimulation, and structured neurorehabilitation programmes to address the neurological components of ME/CFS.
Wearable technology trials to objectively measure activity levels, sleep quality, and post-exertional malaise. These aim to develop reliable biomarkers for diagnosis and treatment response monitoring.
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ME/CFS has historically been underfunded in research, but this is changing. The COVID-19 pandemic and recognition of Long COVID have significantly increased research investment. The UK now has dedicated ME/CFS research centres and the NIHR has committed substantial funding for new trials.
Some trials specifically recruit patients with overlapping conditions, while others exclude them to isolate treatment effects. Check individual eligibility criteria. Many ME/CFS patients also have fibromyalgia, so researchers are increasingly designing trials that reflect this reality.
LDN is a very low dose of a drug normally used for addiction treatment. At low doses, it may modulate the immune system and reduce neuroinflammation. Several small trials and observational studies have shown promise for fatigue and pain reduction in ME/CFS.
Yes. The NHS has specialist ME/CFS services that participate in research, and the NIHR funds ME/CFS trials across the UK. Your GP can refer you to a specialist service, and your specialist can tell you about current trials.
Use our search above to find trials matching your condition and location. Review eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.