Find recruiting clinical trials for coeliac disease in the UK — including gluten desensitisation approaches, therapeutic vaccines, enzyme supplements, and drug treatments to protect against accidental gluten exposure. See your treatment pathway and where trials fit in.
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Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Recently diagnosed and starting gluten-free diet
Standard: Strict gluten-free diet, nutritional assessment, vitamin and mineral supplementation
Managing well on gluten-free diet with regular monitoring
Standard: Ongoing gluten-free diet, annual antibody testing, bone density monitoring
Persistent symptoms and villous atrophy despite strict gluten-free diet
Standard: Steroids, immunosuppressants, specialist centre referral, enteral nutrition
Antibody positive but normal biopsy, or symptoms despite gluten-free diet
Standard: Repeat endoscopy, rule out complications, specialist dietitian review
Nexvax2 and similar approaches aim to desensitise the immune system to gluten peptides through controlled exposure, similar to allergy immunotherapy. The goal is gluten tolerance.
Oral enzyme supplements (ALV003, AN-PEP) designed to break down gluten in the stomach before it triggers an immune response, providing protection against accidental exposure.
Drugs like larazotide acetate that seal the intestinal barrier, preventing gluten peptides from crossing into the tissue where they trigger the immune response.
Novel drugs targeting interleukin-15 and other immune pathways specific to coeliac disease, aiming to suppress the autoimmune response without general immunosuppression.
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There is currently no cure, but several promising approaches are being tested. Therapeutic vaccines, gluten-degrading enzymes, and drugs that protect the intestinal lining aim to enable people with coeliac disease to tolerate gluten.
Yes. In fact, most trials require participants to be on a gluten-free diet. Some trials may briefly introduce small amounts of gluten under medical supervision to test whether the treatment protects against exposure.
A rare condition where the intestine does not heal despite a strict gluten-free diet for over 12 months. It affects about 1% of coeliac patients and requires specialist treatment. Several trials target this specific group.
Yes. Some NHS gastroenterology departments participate in coeliac disease trials, particularly at major teaching hospitals. Your gastroenterologist can refer you to active studies.
Use our search above to find trials matching your condition and location. Review eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.