Find recruiting clinical trials for colorectal cancer in the UK � colon, rectal, and bowel cancer subtypes. See your treatment pathway and where trials fit in.
Free to use � Live data from ClinicalTrials.gov � Updated hourly
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Initial systemic treatment for metastatic disease
Standard: FOLFOX or FOLFIRI + Bevacizumab or Cetuximab (RAS wild-type)
After progression on 1st-line therapy
Standard: Switch chemotherapy backbone + targeted therapy
After multiple lines � clinical trials are especially important
Standard: Regorafenib, TAS-102, or clinical trial
RAS and BRAF mutations affect which targeted therapies will work. Anti-EGFR therapies (cetuximab, panitumumab) only work in RAS wild-type tumours. BRAF V600E mutations indicate poorer prognosis and specific treatment approaches.
Microsatellite instability (MSI-H) or deficient mismatch repair (dMMR) occurs in about 5% of metastatic CRC. These patients respond exceptionally well to immunotherapy (pembrolizumab).
About 3-5% of CRC tumours overexpress HER2. Emerging evidence supports HER2-targeted combinations (trastuzumab + pertuzumab or trastuzumab + lapatinib) in this subgroup.
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Yes. Trials for early-stage disease investigate neoadjuvant approaches, shorter courses of chemotherapy, organ-preserving strategies, and surveillance protocols after treatment.
Current trials study immunotherapy for MSI-H tumours, novel combinations for KRAS-mutant disease, liquid biopsy-guided treatment, and targeted therapies for specific molecular subtypes.
Absolutely. Most colorectal cancer trials target metastatic or advanced disease. Options include first-line combination studies, later-line targeted therapies, and immunotherapy for MSI-H patients.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.