Explore emerging treatments from hormonal therapies to novel non-hormonal approaches.
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Initial treatment for confirmed or suspected endometriosis
Standard: Pain management (NSAIDs), hormonal contraception, progestins
When first-line treatment does not adequately control symptoms
Standard: GnRH agonists/antagonists, higher-dose progestins, laparoscopic surgery
Advanced disease involving bowel, bladder, or other organs
Standard: Laparoscopic excision surgery by specialist endometriosis centre
Endometriosis treatment while preserving fertility options
Standard: Surgical treatment ± ART/IVF referral
A blood marker often elevated in endometriosis. While not diagnostic alone, it is used in some trials to monitor disease activity and treatment response.
Endometriosis is an inflammatory condition. CRP, IL-6, and TNF-alpha levels are studied in trials of anti-inflammatory treatments.
Estrogen and progesterone receptor expression patterns may predict response to hormonal therapies. Some trials stratify patients by receptor status.
Nerve growth factor (NGF) and other pain-related biomarkers are being studied to develop targeted pain treatments for endometriosis.
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Yes. Several trials are testing non-hormonal approaches including anti-inflammatory agents, dopamine agonists, and anti-angiogenic therapies. These could offer alternatives for patients who cannot tolerate hormonal treatments.
The UK has an active endometriosis research community, with trials running at major NHS hospitals and specialist centres. The NIHR supports several studies, and new trials are opening regularly as understanding of the disease improves.
Some trials specifically focus on fertility-preserving treatments for endometriosis. However, many drug trials exclude women actively trying to conceive. Check eligibility criteria carefully and discuss with your gynaecologist.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.