Find recruiting clinical trials for epilepsy in the UK — including focal seizures, generalised seizures, and drug-resistant epilepsy. See treatment pathways and where trials fit in.
Free to use — Live data from ClinicalTrials.gov — Updated hourly
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Initial treatment after diagnosis
Standard: First anti-seizure medication (Lamotrigine, Levetiracetam, or Valproate)
After first medication fails
Standard: Add or switch to alternative ASM (Topiramate, Zonisamide, Lacosamide)
Seizures persist after 2+ appropriate medications
Standard: Epilepsy surgery evaluation, VNS, deep brain stimulation, or clinical trial
Seizures originating in one area of the brain. May or may not impair awareness. About 60% of epilepsy cases.
Seizures involving both sides of the brain from the start. Includes absence seizures, tonic-clonic seizures, and myoclonic seizures.
Seizures that persist after trying two appropriate anti-seizure medications. About 30% of epilepsy patients. Surgery or devices may help.
Loading trials from ClinicalTrials.gov...
Most epilepsy trials are add-on studies that allow you to continue your current anti-seizure medication. Some compare a new drug against an existing one. The trial team will explain whether any changes to your medication are needed.
Current research includes novel anti-seizure medications (Cenobamate, XEN1101), gene therapies, responsive neurostimulation (RNS), focused ultrasound, and cannabidiol (CBD) formulations for specific epilepsy syndromes.
Most epilepsy trials are outpatient. You may need periodic hospital visits for EEG monitoring, blood tests, or dose adjustments. Some Phase 1 trials may require a short inpatient stay for safety monitoring.
Clinical trials can offer access to treatments not yet available, but they are one of several options. Epilepsy surgery evaluation should also be considered. Discuss all options with your neurologist.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.