Find recruiting clinical trials for gout in the UK — including next-generation urate-lowering drugs, novel anti-inflammatory agents for acute flares, and precision medicine approaches to long-term management. See your treatment pathway and where trials fit in.
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See where clinical trials fit into your treatment journey
Sudden onset of severe joint pain and inflammation
Standard: Colchicine, NSAIDs, corticosteroids, rest and ice
No current symptoms — initiating long-term management
Standard: Allopurinol, febuxostat, lifestyle modification, urate monitoring
Persistent gout with tophi or resistant to standard therapy
Standard: Pegloticase, high-dose xanthine oxidase inhibitors, specialist referral
Gout alongside CKD, cardiovascular disease, or metabolic syndrome
Standard: Adjusted dosing, febuxostat (CKD-friendly), multidisciplinary management
New xanthine oxidase inhibitors and URAT1 transport inhibitors designed to achieve target uric acid levels more effectively with fewer side effects than allopurinol.
Canakinumab and other interleukin-1 beta inhibitors for acute gout flares that are resistant to standard anti-inflammatory treatment, and for flare prevention when starting urate-lowering therapy.
Recombinant uricase therapy for refractory gout, and new biosimilar versions being tested to increase access and reduce cost.
Trials investigating the role of gut microbiome in uric acid metabolism, and structured dietary interventions combined with pharmacotherapy.
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Yes. Many trials specifically recruit patients whose uric acid levels are not controlled on allopurinol, testing whether switching to or adding new drugs can achieve better results.
Anti-IL-1β biologics (like canakinumab) are being tested for severe flares that do not respond to colchicine or NSAIDs. New oral anti-inflammatory drugs with fewer gastrointestinal side effects are also in development.
Yes. NHS rheumatology departments participate in gout trials, particularly for patients with refractory gout or those who cannot tolerate standard treatments like allopurinol.
Diet plays an important role, but most people with gout need medication to reach target uric acid levels. Some trials are testing whether combined dietary and pharmacological approaches work better than either alone.
Use our search above to find trials matching your condition and location. Review eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.