Find recruiting clinical trials for heart failure in the UK � from guideline-directed medical therapy to device-based interventions. See where trials fit into your treatment pathway.
Free to use � Live data from ClinicalTrials.gov � Updated daily
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your care journey
Guideline-Directed Medical Therapy � the four pillars
Standard: ACEi/ARB/ARNI + Beta-blocker + MRA + SGLT2 inhibitor (dapagliflozin or empagliflozin)
When standard GDMT isn't enough
Standard: Hydralazine+nitrate (Black patients), ivabradine, digoxin, or diuretic optimisation
For patients meeting device criteria
Standard: ICD (implantable cardioverter-defibrillator), CRT (cardiac resynchronisation therapy)
When conventional therapies no longer control symptoms
Standard: LVAD (left ventricular assist device), heart transplant evaluation, or palliative care
Heart failure means the heart can't pump blood effectively. Affects over 900,000 people in the UK. Symptoms include breathlessness, ankle swelling, and fatigue. Can be caused by heart attacks, high blood pressure, or valve disease.
Treatments have improved dramatically (SGLT2 inhibitors, ARNI), but many patients still deteriorate. Trials are testing gene therapies, novel molecules, and device innovations that could further improve survival and quality of life.
Heart failure with preserved ejection fraction (HFpEF) affects about half of all HF patients but has fewer treatment options. Many new trials specifically target HFpEF � a major unmet need in cardiology.
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Current trials investigate novel SGLT2 inhibitor uses, cardiac myosin activators, soluble guanylate cyclase stimulators, gene therapy, and device-based approaches including improved cardiac resynchronisation.
Yes. Trials exist for both HFrEF (reduced ejection fraction) and HFpEF (preserved ejection fraction). Historically HFpEF had fewer treatment options, but new trials are specifically targeting this group.
Yes. Device trials study next-generation pacemakers, implantable cardioverter-defibrillators, left ventricular assist devices (LVADs), and innovative approaches like baroreceptor activation therapy.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.