Find recruiting clinical trials for hypertension (high blood pressure) in the UK — including essential, resistant, and pulmonary hypertension. See treatment pathways and where trials fit in.
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Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Initial treatment
Standard: ACEi (Ramipril) or ARB (Losartan) or Calcium channel blocker (Amlodipine)
Combination therapy
Standard: ACEi/ARB + CCB (e.g. Ramipril + Amlodipine)
Triple therapy
Standard: ACEi/ARB + CCB + Thiazide diuretic
Uncontrolled on 3+ drugs
Standard: Spironolactone, renal denervation, or clinical trial
The most common type (95% of cases) — no identifiable cause. Linked to age, weight, diet, and genetics. A major risk factor for heart attacks and strokes.
Blood pressure remaining above target despite 3 or more medications. About 10% of treated hypertensives. Renal denervation and aldosterone antagonists can help.
High blood pressure in the arteries of the lungs. A different and rarer condition requiring specialist treatment. Many targeted therapies available.
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Renal denervation is a minimally invasive procedure that uses radiofrequency energy to disrupt nerves around the kidney arteries, reducing blood pressure. Several UK trials are studying its effectiveness for resistant hypertension.
Yes. Trials for resistant hypertension investigate new medications, renal denervation, aldosterone synthase inhibitors, and combination therapies. If your blood pressure is uncontrolled on 3+ medications, these trials may be relevant.
Many hypertension trials specifically recruit patients with diabetes, as the combination is very common and treatment goals may differ. Some trials investigate blood pressure targets in diabetic patients.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.