Find recruiting clinical trials for irritable bowel syndrome (IBS) in the UK — including IBS-C (constipation), IBS-D (diarrhoea), and IBS-M (mixed). See treatment pathways and where trials fit in.
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See where clinical trials fit into your treatment journey
Initial management
Standard: Dietary modification (low FODMAP), peppermint oil, antispasmodics
Constipation-predominant
Standard: Linaclotide, Prucalopride, or fibre supplements
Diarrhoea-predominant
Standard: Loperamide, low-dose Amitriptyline, Rifaximin, or Eluxadoline
Persistent symptoms despite treatment
Standard: Gut-directed hypnotherapy, CBT, or clinical trial
IBS with predominantly constipation. Bloating and abdominal discomfort are common. New secretagogues like Linaclotide have improved treatment options.
IBS with predominantly diarrhoea. Urgency and frequency can significantly impact daily life. Rifaximin (a targeted antibiotic) has shown benefit.
Alternating between constipation and diarrhoea. The most challenging subtype to treat. Often requires flexible treatment approaches.
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Yes. Some trials compare the low FODMAP diet against other dietary approaches, investigate personalised nutrition using gut microbiome data, or study digital tools to help patients follow the diet.
Current research includes new secretagogues, microbiome-targeted therapies (probiotics, prebiotics, faecal microbiota transplantation), gut-directed hypnotherapy apps, and novel pain modulators targeting visceral hypersensitivity.
Most IBS trials specify whether they target IBS-C, IBS-D, or IBS-M. Check the eligibility criteria for your subtype. Some trials accept all subtypes but analyse results separately.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.