Find recruiting clinical trials for lupus in the UK — including systemic lupus erythematosus (SLE), lupus nephritis, and cutaneous lupus. See treatment pathways and where trials fit in.
Free to use — Live data from ClinicalTrials.gov — Updated hourly
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Skin and joint involvement
Standard: Hydroxychloroquine + NSAIDs
More active disease, organ involvement
Standard: Add Azathioprine, Methotrexate, or Mycophenolate
Kidney or other major organ involvement
Standard: Mycophenolate + steroids, Belimumab, or Anifrolumab
Despite standard immunosuppression
Standard: Rituximab, clinical trial, or novel targeted therapy
Autoimmune disease affecting multiple organs including skin, joints, kidneys, and nervous system. Much more common in women, particularly of Afro-Caribbean and Asian origin.
Kidney inflammation caused by lupus. A serious complication requiring aggressive treatment. About 40% of SLE patients develop kidney involvement.
Lupus affecting primarily the skin. Includes discoid lupus and subacute cutaneous lupus. May or may not progress to systemic disease.
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Exciting new approaches include Anifrolumab (anti-interferon), Obinutuzumab, Voclosporin (for lupus nephritis), and multiple novel targeted therapies. Several are in Phase 3 trials in the UK.
Most trials allow you to continue background Hydroxychloroquine as it is standard care. Trials typically add the investigational treatment on top of your existing medication.
Yes. Many lupus trials consider pregnancy-related concerns and may include specific arms for women planning pregnancy. Some trials study lupus during pregnancy or post-partum. Ask the trial team about family planning requirements.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.