Find recruiting clinical trials for menopause and perimenopause in the UK — including next-generation HRT formulations, novel non-hormonal treatments for hot flushes, cognitive function studies, and bone health interventions. See your treatment pathway and where trials fit in.
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See where clinical trials fit into your treatment journey
Transitional phase with irregular periods and early symptoms
Standard: Lifestyle modification, low-dose HRT if needed, cognitive behavioural therapy for mood changes
Hot flushes, night sweats, mood changes, vaginal dryness
Standard: HRT (oestrogen + progestogen), tibolone, vaginal oestrogen, SSRIs/SNRIs for flushes
Long-term cardiovascular, bone, and cognitive health
Standard: Bisphosphonates, calcium/vitamin D, cardiovascular risk management, cognitive monitoring
Menopause before age 40 or after surgery
Standard: HRT recommended until average menopause age (51), bone density monitoring, psychological support
Trials testing new HRT delivery methods including transdermal patches with adjustable dosing, longer-acting injectable formulations, and bioidentical hormone preparations with better safety profiles.
Neurokinin-3 receptor (NK3R) antagonists like fezolinetant — a entirely new drug class that blocks hot flushes at the brain level without hormones. Represents the biggest advance in non-hormonal menopause treatment in decades.
Trials investigating "brain fog" during menopause, testing whether HRT timing, cognitive training, or novel drugs can protect memory and concentration during the menopausal transition.
Long-term trials testing whether newer osteoporosis drugs (romosozumab), combined with menopause-specific interventions, can better protect against fractures and heart disease in post-menopausal women.
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Yes. Fezolinetant (Veozah) is a new NK3 receptor antagonist that blocks hot flushes without hormones. Several similar drugs are in UK trials. These are particularly important for women who cannot take HRT due to breast cancer history or other risk factors.
Some trials require participants to stop current HRT (with medical supervision), while others test add-on or switch treatments. Check each trial's specific criteria. Never stop HRT without medical advice.
Yes. Several UK trials are specifically studying cognitive changes during menopause, including memory, concentration, and processing speed. Some test whether timing of HRT initiation affects long-term brain health — the "window of opportunity" hypothesis.
Yes. Many NHS menopause clinics participate in research. The British Menopause Society supports trial recruitment, and major teaching hospitals frequently run menopause studies. Ask your menopause specialist about current opportunities.
Use our search above to find trials matching your condition and location. Review eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.