Find recruiting clinical trials for migraine in the UK — including chronic migraine, episodic migraine, and cluster headache. See treatment pathways and where trials fit in.
Free to use — Live data from ClinicalTrials.gov — Updated hourly
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Treating individual migraine attacks
Standard: Triptans (Sumatriptan), CGRP inhibitors (Rimegepant), or NSAIDs
Reducing attack frequency
Standard: Propranolol, Amitriptyline, Topiramate, or CGRP monoclonal antibodies
15+ headache days per month
Standard: CGRP antibodies (Erenumab, Fremanezumab), Botox, or clinical trial
Severe unilateral pain in clusters
Standard: Oxygen therapy, Verapamil, or clinical trial
15 or more headache days per month, with at least 8 being migraine. Significantly impacts work, social life, and mental health.
Fewer than 15 headache days per month. The most common form. New CGRP-targeting treatments have transformed prevention.
Extremely severe unilateral pain in cyclical patterns or "clusters". Often called the most painful condition known. New treatments are urgently needed.
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CGRP (calcitonin gene-related peptide) is a protein involved in migraine attacks. CGRP inhibitors block this pathway — either as monthly injections (Erenumab, Fremanezumab) for prevention, or as oral tablets (Rimegepant) for acute treatment.
Yes. Many trials specifically target episodic migraine (4-14 migraine days per month). Prevention trials for episodic migraine are among the most common.
Yes. Some trials investigate neurostimulation devices (external trigeminal nerve stimulation, vagus nerve stimulation), behavioural interventions, and digital therapeutics for migraine.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.