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Osteoporosis Clinical Trials

Find recruiting clinical trials for osteoporosis in the UK — including post-menopausal, male, and glucocorticoid-induced osteoporosis. See treatment pathways and where trials fit in.

Free to use — Live data from ClinicalTrials.gov — Updated hourly

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Osteoporosis Treatment Pathway

See where clinical trials fit into your treatment journey

1st Line — Oral

Initial treatment

Standard: Alendronic acid (Fosamax) or Risedronate — weekly oral bisphosphonate

Anabolic

Building new bone

Standard: Teriparatide (Forteo) or Romosozumab (Evenity) for high fracture risk

Denosumab

Subcutaneous injection

Standard: Denosumab (Prolia) — twice-yearly injection for those intolerant of bisphosphonates

About Osteoporosis

Post-Menopausal

The most common group. Oestrogen decline after menopause accelerates bone loss. About 1 in 2 women over 50 will break a bone due to osteoporosis.

Male Osteoporosis

Less commonly recognised but affects about 1 in 5 men over 50. Often under-diagnosed. Testosterone deficiency is a contributing factor.

Glucocorticoid-Induced

Caused by long-term steroid use (e.g. Prednisolone). Rapid bone loss can occur. Requires early intervention with bone-protective therapy.

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Frequently Asked Questions

Romosozumab (Evenity) is a bone-building (anabolic) treatment given as monthly injections for 12 months. It is approved by NICE for postmenopausal women at very high fracture risk. Trials are exploring expanded use.

Most osteoporosis trials run 1-3 years to measure changes in bone mineral density and fracture rates. Some long-term extension studies continue for 5-10 years.

Yes. Many trials specifically include men, and some focus exclusively on male osteoporosis. Treatment options for men are expanding, and trials are helping establish best practices.

How to Join a Osteoporosis Clinical Trial

1

Search

Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.

2

Discuss

Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.

3

Contact

Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.

4

Enrol

If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.

🗺️ Related Pathway: Musculoskeletal & Pain Pathway · Women\'s Health Pathway