Find recruiting clinical trials for polycystic ovary syndrome (PCOS) in the UK — including novel hormonal treatments, metabolic therapies targeting insulin resistance, fertility interventions, and precision medicine approaches. See your treatment pathway and where trials fit in.
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See where clinical trials fit into your treatment journey
Irregular cycles, acne, hirsutism
Standard: Combined oral contraceptive pill, cyclical progestogens, anti-androgen therapy (cyproterone acetate)
Weight gain, impaired glucose tolerance, elevated insulin
Standard: Metformin, lifestyle modification, GLP-1 receptor agonists, dietary intervention
Difficulty conceiving due to anovulation
Standard: Letrozole, clomifene citrate, gonadotropins, IVF if needed
Addressing cardiovascular, diabetes, and endometrial cancer risk
Standard: Regular screening, weight management, metabolic monitoring, endometrial protection
Trials testing tirzepatide (Mounjaro), semaglutide (Wegovy), and other incretin therapies for PCOS-related insulin resistance, weight management, and hormonal improvement. These drugs may address multiple PCOS symptoms simultaneously.
New topical and systemic anti-androgen treatments targeting excess testosterone production and its effects (hirsutism, acne, hair loss) without the side effects of current options like spironolactone or cyproterone.
Trials testing new ovulation induction protocols, including letrozole combinations, mild IVF approaches, and adjuvant therapies to improve egg quality and pregnancy rates in PCOS patients.
Research into the gut microbiome's role in PCOS and whether targeted probiotic or dietary interventions can improve metabolic and hormonal outcomes. Genetic profiling trials aim to personalise PCOS treatment.
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Yes. Many PCOS trials specifically focus on fertility and ovulation induction. However, some drug trials (especially those testing anti-androgens or weight loss drugs) may require contraception during participation. Check each trial's specific requirements.
Yes. Several UK and international trials are testing GLP-1 receptor agonists (semaglutide, liraglutide) and dual agonists (tirzepatide) for PCOS. These target insulin resistance, weight gain, and may improve hormonal balance and menstrual regularity.
Topical anti-androgen creams, laser therapy combined with medical treatment, and novel enzymatic hair growth inhibitors are all in clinical testing. Some trials are also testing whether GLP-1 drugs reduce androgen levels and improve hirsutism scores.
PCOS affects up to 1 in 10 women of reproductive age in the UK, making it one of the most common endocrine conditions. Research funding has increased significantly, particularly for metabolic and fertility-focused trials. The UK is a major hub for PCOS research.
Use our search above to find trials matching your condition and location. Review eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.