Find recruiting clinical trials for kidney cancer (RCC) in the UK � from surgical approaches to immunotherapy-TKI combinations. See where trials fit into your treatment pathway.
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Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Partial or radical nephrectomy for localised disease, sometimes with surveillance or adjuvant therapy
Standard: Partial nephrectomy (kidney-sparing) or radical nephrectomy; active surveillance for small renal masses
Tyrosine kinase inhibitors target tumour blood vessel formation
Standard: Pazopanib, sunitinib, or cabozantinib as first-line for patients where immunotherapy isn't suitable
Combination immunotherapy has become the standard first-line approach for most advanced RCC
Standard: Pembrolizumab + axitinib, nivolumab + cabozantinib, or ipilimumab + nivolumab (poor risk)
After first-line progression, trials test sequential therapies and new mechanisms
Emerging: Belzutifan (HIF-2a inhibitor), lenvatinib + pembrolizumab, novel bispecific antibodies, and CAR-T approaches
Renal cell carcinoma is the most common type of kidney cancer in adults, accounting for about 13,300 new cases per year in the UK. Clear cell RCC (ccRCC) makes up about 75% of cases. Risk factors include smoking, obesity, and family history. Many are found incidentally on imaging.
RCC has been a success story for immunotherapy � from early cytokine treatments to modern IO+TKI combinations, survival has improved significantly. But many patients still progress. Trials are testing next-generation approaches including HIF-2a inhibitors and personalised immunotherapy.
Treatment choices depend on your IMDC (International Metastatic RCC Database Consortium) risk score � based on blood tests, performance status, and time from diagnosis to treatment. Your oncologist uses this to determine whether you're favourable, intermediate, or poor risk, which guides therapy selection.
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Active trials study next-generation immunotherapy combinations, antibody-drug conjugates, HIF-2α inhibitors (Belzutifan), CAR-T cell therapy, and novel tyrosine kinase inhibitors. Multiple Phase 3 trials are running in the UK.
Yes. Immunotherapy combinations (Nivolumab + Ipilimumab, Pembrolizumab + Axitinib) are now standard first-line treatment for advanced RCC. Clinical trials are testing next-generation combinations and sequences.
Yes. While most trials focus on clear cell RCC, some specifically target non-clear cell subtypes (papillary, chromophobe, collecting duct). Treatment options for these rarer subtypes are expanding.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.
Learn about immunotherapy combinations, HIF-2a inhibitors, CAR-T therapy, and adjuvant treatment for kidney cancer.
Renal Cell Carcinoma Clinical Trials UK (2026) →