Find recruiting clinical trials for schizophrenia in the UK — including acute exacerbation, treatment-resistant, and negative symptoms. See treatment pathways and where trials fit in.
Free to use — Live data from ClinicalTrials.gov — Updated hourly
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
First psychotic episode
Standard: Atypical antipsychotic (Risperidone, Olanzapine, Aripiprazole) + psychosocial support
Relapse of positive symptoms
Standard: Optimise antipsychotic dose or switch agent
No response to 2+ antipsychotics
Standard: Clozapine (only approved drug for TRS)
Lack of motivation, blunted affect
Standard: Cariprazine, psychosocial interventions, or clinical trial
Relapse with positive symptoms such as hallucinations, delusions, and disorganised thinking. Usually requires urgent medication adjustment.
About 30% of schizophrenia patients do not respond adequately to standard antipsychotics. Clozapine is the gold standard but has significant side effects.
Reduced emotional expression, lack of motivation, social withdrawal. Often more disabling than positive symptoms and harder to treat.
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New approaches include KarXT (a novel muscarinic agonist), TAAR1 agonists (Ulotaront), and improved formulations of existing antipsychotics. Several aim to treat negative symptoms without the side effects of current drugs.
Clozapine is the most effective antipsychotic but requires regular blood monitoring due to the risk of agranulocytosis (dangerous white blood cell drop). It is reserved for treatment-resistant cases after trying at least 2 other antipsychotics.
Yes. Treating negative symptoms (lack of motivation, blunted emotions, social withdrawal) is a major unmet need. Several trials are investigating novel mechanisms specifically targeting these symptoms.
Many people with schizophrenia can provide informed consent. If someone lacks capacity, a designated representative can consent on their behalf. The trial team will assess capacity and provide support.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.