Find recruiting clinical trials for type 1 diabetes in the UK — including immunotherapy to preserve beta cells, artificial pancreas systems, stem cell therapies, and islet cell transplantation. See your treatment pathway and where trials fit in.
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Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Within 3 months of diagnosis — beta cell preservation trials
Standard: Immunotherapy, anti-CD3 (teplizumab), anti-thymocyte globulin, low-dose anti-IL-2
Managing with insulin injections or pump
Standard: Multiple daily injections, insulin pump, hybrid closed-loop systems
With diabetic neuropathy, retinopathy, or nephropathy
Standard: ACE inhibitors, SGLT2 inhibitors, screening and specialist referral
Eligible for islet or stem cell transplantation
Standard: Islet cell transplant, stem cell-derived beta cells, encapsulation therapies
Trials testing drugs like teplizumab and anti-thymocyte globulin to slow or stop the immune attack on insulin-producing beta cells, particularly in newly diagnosed patients.
Closed-loop insulin delivery systems (hybrid and fully automated) that use continuous glucose monitors and algorithm-driven pumps to manage blood sugar without manual input.
Vertex VX-880 and similar stem cell-derived islet cell therapies aim to restore natural insulin production. Early trial results have been groundbreaking.
Donor islet cells are transplanted into the liver to restore insulin production. Available on the NHS for severe hypoglycaemia unawareness.
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Yes. While some trials target newly diagnosed patients (within 3 months), many focus on established type 1 diabetes — testing new insulin delivery technology, complications treatments, and cell therapies for people at any disease duration.
A closed-loop system combines a continuous glucose monitor with an insulin pump, controlled by an algorithm that automatically adjusts insulin delivery. Several UK trials are testing next-generation fully automated systems.
Yes. Vertex VX-880 (stem cell-derived islet cells) has shown remarkable early results in US trials, and UK sites are expected to participate in later-phase studies. Several other stem cell approaches are also in clinical testing.
Most therapeutic trials do not pay participants, but cover trial-related costs and travel. Healthy volunteer Phase 1 trials (often for new insulins or devices) may offer payment. Check each trial listing for details.
Use our search above to find trials matching your condition and location. Review eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.