Find recruiting clinical trials for type 2 diabetes in the UK � from first-line metformin to cutting-edge GLP-1 and dual-agonist therapies. See where trials fit into your treatment pathway.
Free to use � Live data from ClinicalTrials.gov � Updated daily
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your care journey
Initial treatment after diagnosis
Standard: Metformin + diet/exercise changes. Targets HbA1c below 48 mmol/mol
When metformin alone isn't enough
Standard: GLP-1 receptor agonists (semaglutide, dulaglutide) or SGLT2 inhibitors (dapagliflozin, empagliflozin)
Combining multiple drug classes for better control
Standard: Metformin + GLP-1 + SGLT2, or adding DPP-4 inhibitors, pioglitazone
When oral/injectable therapies can't maintain targets
Standard: Basal insulin, insulin intensification, tirzepatide (dual GIP/GLP-1), or newer agents
A condition where the body doesn't produce enough insulin or becomes resistant to it. Affects about 4.3 million people in the UK. Can cause heart disease, kidney damage, eye problems, and nerve damage if not well controlled.
The diabetes treatment landscape has transformed with GLP-1 agonists and dual agonists (tirzepatide). Trials are pushing further � triple agonists, oral semaglutide, islet cell regeneration, and treatments addressing cardiovascular and kidney complications alongside blood sugar.
Modern diabetes care focuses on more than blood sugar. SGLT2 inhibitors protect kidneys and hearts. Many trials now specifically test cardiovascular and renal outcomes, not just HbA1c reduction.
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Active research includes once-weekly insulin, triple agonists (combining GLP-1, GIP, and glucagon receptor agonism), oral GLP-1 tablets, beta cell regeneration therapy, and digital health interventions for glucose management.
Yes. Some trials investigate whether intensive weight loss programmes (very low calorie diets), bariatric surgery, or novel medications can achieve diabetes remission. The DiRECT trial showed remission is possible.
Yes. Many trials recruit insulin-treated patients to test new combinations, simplified regimens, or novel insulins. Some study switching from insulin to newer non-insulin therapies.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.