Find recruiting clinical trials for UC in the UK � from first-line 5-ASAs to advanced biologic and small-molecule therapies. See where trials fit into your treatment pathway.
Free to use � Live data from ClinicalTrials.gov � Updated daily
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
First-line treatment for mild to moderate ulcerative colitis
Standard: Mesalazine (oral and/or rectal), sulfasalazine, or olsalazine
When 5-ASAs alone aren't enough to control inflammation
Standard: Azathioprine, 6-Mercaptopurine, Methotrexate, or corticosteroids
For moderate-to-severe UC unresponsive to conventional therapy
Standard: Infliximab, Adalimumab, Golimumab, Vedolizumab, or Ustekinumab
After biologic failure � next-generation oral therapies
Standard: Tofacitinib, Upadacitinib, Ozanimod, or clinical trial
A chronic inflammatory bowel disease causing inflammation and ulcers in the colon and rectum. Affects about 120,000 people in the UK. Symptoms include bloody diarrhoea, abdominal pain, and fatigue.
Up to 40% of UC patients don't maintain remission with current treatments. Clinical trials offer access to new biologics, JAK inhibitors, and novel anti-inflammatory approaches before they're widely available.
Some patients develop acute severe flares requiring hospital treatment (IV steroids, ciclosporin, or infliximab rescue). Trials specifically targeting acute severe colitis are particularly important.
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Novel approaches include oral small molecules (JAK inhibitors, S1P modulators like Ozanimod), anti-TL1A biologics, microbiome-based therapies, and next-generation anti-integrin agents.
Some trials specifically target patients facing colectomy (surgical removal of the colon), testing rescue therapies that may induce remission and allow you to keep your colon.
Yes. Paediatric ulcerative colitis trials study age-appropriate dosing, safety in younger patients, and early intervention strategies. Several UK centres specialise in paediatric IBD research.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.