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Infectious Disease Clinical Trials

Infectious disease research in the UK has expanded dramatically since COVID-19, with increased funding, infrastructure, and public awareness. From long COVID recovery studies to next-generation HIV treatments and hepatitis cures, clinical trials are driving progress against some of the world's most persistent infections.

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Long COVID Research

Long COVID affects an estimated 2 million people in the UK. Clinical trials are testing anti-inflammatory drugs, antivirals, exercise rehabilitation programmes, and cognitive behavioural approaches. The NHS England Long COVID trial programme is one of the largest research efforts globally, with multiple studies recruiting through GP practices and specialist clinics.

HIV Treatment and Prevention

While HIV is now a manageable chronic condition, trials continue to pursue a cure and improved prevention. UK HIV trials are testing long-acting injectable antiretrovirals (monthly or bi-monthly dosing instead of daily pills), broadly neutralising antibodies for both treatment and prevention, and gene editing approaches (CRISPR) aimed at eliminating latent HIV from cells.

Hepatitis C Elimination and Beyond

The UK aims to eliminate hepatitis C as a public health concern. Direct-acting antivirals cure over 95% of cases, but trials continue to test shorter treatment courses, retreatment options for rare failures, and approaches for patients co-infected with HIV. Hepatitis B trials are exploring functional cure strategies using RNA interference and immune modulators.

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Frequently Asked Questions

Are there trials for long COVID treatment?
Yes. The UK has one of the world's largest long COVID research programmes, with trials testing anti-inflammatory drugs, antivirals, and rehabilitation approaches. Ask your GP about referral to a long COVID clinic, which can connect you to current trials.
Can I join an HIV trial if my viral load is undetectable?
Yes. Many HIV trials specifically recruit people with undetectable viral load to test treatment simplification, long-acting formulations, and cure strategies. Your HIV clinic can advise on available trials.

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