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Respiratory Conditions Clinical Trials

Respiratory conditions are among the most common reasons for NHS visits and hospital admissions in the UK. Clinical trials are driving advances in biologic therapies for severe asthma, gene therapy for cystic fibrosis, and novel interventions for COPD and sleep apnoea.

4 Conditions 1 Treatments 4 Comparisons

Biologic Therapies for Severe Asthma

Biologic drugs targeting specific immune pathways (such as IL-5, IL-4, and IgE) have revolutionised treatment for severe, uncontrolled asthma. UK trials continue to test new biologics, biosimilar versions, and combination approaches. If you have severe asthma that is not well controlled with standard inhalers, you may be eligible for biologic trials.

Gene Therapy and Cystic Fibrosis

The UK is a world leader in cystic fibrosis gene therapy research. While CFTR modulators have transformed care for many patients, gene therapy aims to address the underlying genetic defect regardless of the specific CFTR mutation. Clinical trials at centres like the Oxford Gene Therapy Consortium are testing viral and non-viral gene delivery methods.

COPD and Novel Anti-Inflammatory Approaches

COPD clinical trials are exploring new anti-inflammatory drugs, stem cell therapies, and lung volume reduction techniques. Many trials focus on reducing exacerbations — the dangerous flare-ups that lead to hospitalisation. If you have moderate to severe COPD with frequent exacerbations, several UK trials may be suitable.

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Frequently Asked Questions

Can I join a respiratory trial if I smoke?
Some trials exclude current smokers while others specifically target smoking-related conditions. Many COPD trials accept current or former smokers. The trial team will assess your suitability based on your full medical history.
What is gene therapy for cystic fibrosis?
Gene therapy for CF aims to deliver a healthy copy of the CFTR gene to the lungs, potentially treating the root cause regardless of the specific mutation. Unlike CFTR modulators (which work for specific mutations), gene therapy could benefit all CF patients. Clinical trials are ongoing in the UK.

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