Neurology Clinical Trials in the UK (2026): Alzheimer's, Parkinson's, MS, Epilepsy and More
Neurological conditions affect over 10 million people in the UK and represent one of the most exciting frontiers in clinical research. Disease-modifying treatments for Alzheimer's, neurostimulation for epilepsy and Parkinson's, and stem cell therapies for MS are all advancing through UK clinical trials.
Alzheimer's Disease: A New Treatment Era
The approval of lecanemab and donanemab — drugs that actually slow Alzheimer's disease progression by clearing amyloid plaques — has transformed the landscape. UK trials continue to test these drugs in broader patient populations, earlier disease stages, and in combination with other approaches. Trials targeting tau protein, neuroinflammation, and neuroprotection are also advancing. If you or a loved one has early Alzheimer's or mild cognitive impairment, several UK trials may be suitable.
Parkinson's Disease: Beyond Symptom Management
Parkinson's trials are increasingly focused on disease modification rather than just managing symptoms with dopamine replacement. Trials targeting alpha-synuclein (the protein that clumps in Parkinson's) aim to slow or halt disease progression. Other trials test enhanced delivery systems for existing drugs, deep brain stimulation refinements, and gene therapy approaches. The UK Parkinson's Excellence Network connects patients with trials across the country.
Multiple Sclerosis: Expanding Treatment Options
MS treatment has been transformed by disease-modifying therapies (DMTs), but many patients still experience disease progression. Current UK trials are testing BTK inhibitors (which cross the blood-brain barrier to target inflammation in the brain), novel stem cell transplantation protocols, and remyelination therapies that could repair damaged nerve coatings. The UK MS Register helps match patients to appropriate trials.
How to Find Neurology Trials
Start with your neurologist or specialist nurse — they know about trials at your hospital and through regional networks. The NIHR Neurological Disorders Specialty Group coordinates trials nationally. Our individual condition pages (linked below) connect you to actively recruiting studies for each specific condition. For rare neurological conditions, patient organisations often maintain trial registries and can provide guidance.