Find recruiting clinical trials for cystic fibrosis in the UK — including CFTR modulator studies, gene therapy, infection management, and lung function preservation. See treatment pathways by mutation class.
Free to use — Live data from ClinicalTrials.gov — Updated hourly
Answer a few questions about your condition and we'll match you to the most relevant clinical trials.
See where clinical trials fit into your treatment journey
Targeting the underlying CFTR defect
Standard: Kaftrio (elexacaftor/tezacaftor/ivacaftor) for eligible mutations
Treating and preventing lung infections
Standard: Antibiotics (IV and inhaled), azithromycin, CF-specific regimens
Maintaining and improving lung health
Standard: Airway clearance, hypertonic saline, dornase alfa
Severe lung disease and transplant consideration
Options: Lung transplant assessment, advanced therapies
Live results from ClinicalTrials.gov — recruiting now in the UK
Yes. Gene therapy trials for CF are actively developing, using viral vectors and lipid nanoparticles to deliver functional CFTR gene copies to lung cells. UK-based research has been at the forefront of CF gene therapy development.
Several trials specifically target rare CF mutations not covered by current triple therapy (Kaftrio/Kalydeco). Next-generation correctors and potentiators aim to expand coverage to 95%+ of CF patients.
Yes. Many trials actively recruit adults, reflecting the growing adult CF population. Some trials focus specifically on adult complications including CFRD, lung transplant candidates, and age-related CF concerns.
Use our search above to find trials that match your condition and location. Review the eligibility criteria carefully.
Talk to your GP or specialist about any trials you are interested in. They can help determine if a trial is appropriate for you.
Reach out to the trial team directly using the contact information on the ClinicalTrials.gov listing. They will guide you through screening.
If you meet the criteria and decide to participate, you will go through informed consent and begin the trial process.