Find actively recruiting stem cell transplant clinical trials in the UK. From bone marrow transplants to novel conditioning regimens and graft engineering for blood cancers and autoimmune diseases.
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Stem cell transplantation replaces damaged or destroyed bone marrow with healthy stem cells that can regenerate the blood and immune system. It is a curative treatment for many blood cancers and increasingly being studied for autoimmune diseases and genetic disorders.
There are two main types: Autologous transplant uses your own stem cells, collected before high-dose chemotherapy and reinfused afterwards to "rescue" your bone marrow. Allogeneic transplant uses donor stem cells (from a matched sibling or unrelated donor) which also provide a graft-versus-cancer immune effect. The process involves conditioning chemotherapy (sometimes radiation), stem cell infusion, and a recovery period of 2-6 weeks while the new immune system engrafts.
Actively recruiting studies in the United Kingdom
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Autologous transplants use your own stem cells — there is no risk of rejection but also no immune attack on remaining cancer. Allogeneic transplants use donor cells — they carry risk of graft-versus-host disease (GvHD) but also provide a powerful graft-versus-cancer effect. Your doctor will recommend the best approach based on your disease, age, and fitness.
Autologous transplant recovery typically takes 2-3 months. Allogeneic transplant recovery is longer — 3-6 months for immune recovery and up to a year for full immune reconstitution. You will need regular blood tests, medications to prevent complications, and close monitoring during the first year.
Clinical trials are investigating autologous HSCT for severe, treatment-resistant autoimmune diseases including multiple sclerosis, Crohn's disease, and systemic sclerosis. The aim is to "reset" the immune system. Results have been promising for carefully selected patients, though it remains experimental and requires referral to a specialist centre.
Stem Cell Transplant is used across multiple conditions. Select your condition for targeted results.
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