Find actively recruiting targeted therapy clinical trials in the UK. Learn about kinase inhibitors, monoclonal antibodies, and precision medicine targeting specific genetic mutations in cancer.
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Targeted therapy uses drugs designed to interact with specific molecules involved in cancer growth and progression. Unlike chemotherapy which attacks all fast-dividing cells, targeted therapy zeroes in on genetic mutations, proteins, or blood vessel formation that are unique to cancer cells.
Targeted therapies work through several mechanisms: Small molecule inhibitors enter cells and block signalling pathways (e.g., EGFR inhibitors, BRAF inhibitors). Monoclonal antibodies attach to specific proteins on cell surfaces. Angiogenesis inhibitors starve tumours of blood supply. PARP inhibitors exploit DNA repair weaknesses in BRCA-mutated cancers. Treatment selection is guided by biomarker testing — matching the right drug to your tumour's genetic profile.
Actively recruiting studies in the United Kingdom
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Chemotherapy kills all rapidly dividing cells, causing widespread side effects. Targeted therapy specifically blocks molecules that drive cancer growth, often resulting in fewer and different side effects. Targeted therapy usually requires genetic testing to confirm a matching mutation — it only works if your cancer has the specific target.
Yes, most targeted therapies require biomarker testing to confirm you have the specific mutation or protein the drug targets. This typically involves a tumour biopsy for genomic profiling, blood tests (liquid biopsy), or immunohistochemistry. NHS genomic testing is expanding rapidly.
Yes, cancers can develop resistance through secondary mutations, pathway bypass, or tumour evolution. This is why clinical trials for next-generation targeted therapies, combination approaches, and resistance-overcoming strategies are so important. When one targeted therapy stops working, another may still be effective.
Targeted Therapy is used across multiple conditions. Select your condition for targeted results.
How does this treatment compare with alternatives?