💊 Treatment Type

Hormone Therapy Clinical Trials UK

Find actively recruiting hormone therapy clinical trials in the UK. Explore hormonal treatments being tested for breast cancer, prostate cancer, endometriosis, menopause, thyroid disorders, and other hormone-sensitive conditions.

Free to use — Live data from ClinicalTrials.gov — Updated hourly

What Is Hormone Therapy?

Hormone therapy (also called endocrine therapy or hormonal therapy) uses medicines that block, add, or modify hormones in the body to treat disease. Some cancers are driven by hormones — such as oestrogen-dependent breast cancer and androgen-dependent prostate cancer — making hormone therapy a cornerstone of treatment. Hormone therapy is also used for non-cancer conditions including endometriosis, menopause, polycystic ovary syndrome, and thyroid disorders. Clinical trials are constantly refining these approaches.

Types of Hormone Therapy in Clinical Trials

Aromatase Inhibitors

Drugs like anastrozole, letrozole, and exemestane that block oestrogen production in postmenopausal women. Trials test longer durations, earlier initiation, and combination with CDK4/6 inhibitors in breast cancer.

SERMs & SERDs

Selective oestrogen receptor modulators (tamoxifen, raloxifene) and degraders (elacestrant, fulvestrant). Trials compare new oral SERDs against standard treatments, often in ER+ breast cancer with ESR1 mutations.

Androgen Deprivation Therapy (ADT)

Treatments that reduce androgen levels or block androgen receptors in prostate cancer. Trials test intermittent dosing, novel AR inhibitors (enzalutamide, apalutamide, darolutamide), and combinations with other therapies.

GnRH Analogues

Gonadotropin-releasing hormone agonists and antagonists that suppress ovarian or testicular hormone production. Used in prostate cancer, endometriosis, uterine fibroids, and breast cancer. Trials test new delivery methods and indications.

Hormone Replacement Therapy (HRT)

Trials investigating oestrogen, progesterone, and combined HRT formulations for menopause symptoms, bone health, and cardiovascular outcomes. New delivery methods and bioidentical hormones are key research areas.

Thyroid Hormone Therapy

Levothyroxine and combination T3/T4 trials for hypothyroidism, thyroid cancer management (TSH suppression), and optimisation of thyroid replacement dosing. Research explores precision dosing and patient-reported outcomes.

Conditions Using Hormone Therapy in Trials

Hormone therapy is investigated in trials for many hormone-sensitive conditions. Select a condition to explore relevant trials:

🎗ïļ Breast Cancer ðŸ”ĩ Prostate Cancer ðŸĐš Endometriosis ðŸŸĄ Ovarian Cancer ðŸĶ‹ Thyroid Cancer ðŸĐš PCOS ðŸŒĄïļ Menopause ðŸĶī Osteoporosis ðŸŸĪ Colorectal Cancer ðŸĐš Uterine Cancer

FAQs About Hormone Therapy Trials

What is the difference between hormone therapy and chemotherapy?
Hormone therapy works by blocking or adding specific hormones to slow or stop the growth of hormone-sensitive conditions. Chemotherapy directly kills rapidly dividing cells throughout the body. Hormone therapy tends to have different side effects (hot flushes, bone thinning, mood changes) compared to chemotherapy (hair loss, nausea, low blood counts), and is often used long-term rather than in short cycles.
Is hormone therapy only used for cancer?
No. While hormone therapy is a cornerstone of breast and prostate cancer treatment, it is also used in clinical trials for endometriosis (suppression of oestrogen), menopause symptoms (HRT), polycystic ovary syndrome (insulin sensitizers and anti-androgens), thyroid disorders (thyroid hormone replacement), and gender-affirming care. Clinical trials test new hormonal agents across all these areas.
What are selective oestrogen receptor modulators (SERMs)?
SERMs are drugs that block or stimulate oestrogen receptors in different tissues. Tamoxifen, the most well-known SERM, blocks oestrogen in breast tissue while potentially having oestrogen-like effects in bone and uterus. Clinical trials are testing next-generation SERMs with improved tissue selectivity to reduce side effects.
How long do hormone therapy clinical trials typically last?
Hormone therapy trials often last longer than chemotherapy trials because hormonal treatments are typically taken for years rather than months. Adjuvant hormone therapy trials for breast cancer can follow participants for 5–10 years. However, some trials (particularly those testing new agents or combinations) may have shorter treatment phases with longer follow-up periods.

Related Treatment Types

ðŸŽŊ Targeted Therapy

Often combined with hormone therapy — CDK4/6 inhibitors, PI3K inhibitors, and mTOR inhibitors

ðŸ›Ąïļ Immunotherapy

Being tested alongside hormone therapy in resistant cancers and MSI-H tumours

💊 Chemotherapy

Combined with hormone therapy in neoadjuvant and metastatic cancer settings

🧎 PARP Inhibitors

Tested with hormone therapy in BRCA-mutated and HRD-positive breast and ovarian cancer

Ready to Find Hormone Therapy Trials?

Use our Smart Matcher to find actively recruiting hormone therapy trials tailored to your condition and treatment history.

🔍 Search Hormone Therapy Trials